Irina-Elena Lupu

This study shows SULF1, expressed in the epicardium, regulates HSPG sulfation to control cardiac development by modulating signaling and cell fate.

This study identifies a direct origin of lymphatic endothelial cells from non-venous angioblasts, challenging the prevailing view that they primarily derive from venous endothelium.

This study identifies SRSF3 as a key regulator of epicardial formation by controlling cell proliferation and revealing its interactions with cell cycle regulators through single-cell RNA-sequencing and endogenous irCLIP.

This study shows that tissue-resident macrophages are essential for lymphatic vessel growth and patterning during heart development by remodeling the vascular plexus.

The paper investigates the expression of five epicardial markers during murine heart development, showing their co-expression and sequential downregulation, challenging the pre-committed fate model.