Andia N. Redpath

Organ-specific and conserved regulatory logic orchestrates gene expression in the embryonic mesothelium

The paper identifies regulatory elements and transcription factors governing gene expression in the embryonic mesothelium across three organs, revealing conserved and organ-specific mechanisms.

Essential regulation of heparan sulfate proteoglycan signalling controls cell behaviour to support cardiac development

This study shows SULF1, expressed in the epicardium, regulates HSPG sulfation to control cardiac development by modulating signaling and cell fate.

The extracellular heparan sulfatase SULF2 limits myeloid IFNbeta signaling and Th17 responses in inflammatory arthritis.

This study shows that SULF2 limits myeloid IFNβ signaling and Th17 responses in inflammatory arthritis by modulating heparan sulfate remodeling.

Maternal iron deficiency impacts the placental arterial network.

The paper identifies molecular markers for placental arterial and venous endothelial cells and shows maternal iron deficiency impairs the arterial vascular network.

SRSF3 is a key regulator of epicardial formation

This study identifies SRSF3 as a key regulator of epicardial formation by controlling cell proliferation and revealing its interactions with cell cycle regulators through single-cell RNA-sequencing and endogenous irCLIP.

Spatiotemporal analysis reveals significant overlap of key proepicardial markers in the developing murine heart

The paper investigates the expression of five epicardial markers during murine heart development, showing their co-expression and sequential downregulation, challenging the pre-committed fate model.