Deciphering spatial heterogeneity of patient-derived organoids of colorectal tumors for drug discovery
Maxim N. Norkin, Jonathan Bac, Louis McConnell, Christophe Cisarovsky, Marina Alexandre Gaveta, Sylvie André, Simon Tanaka, Antonia Digklia, Sylke Hoehnel, Stephanie Tissot, Joerg Huelsken, Marianna Rapsomaniki, Raphaël Gottardo, Krisztián Homicskó
This study develops a platform to analyze spatial heterogeneity in colorectal tumor organoids using spatial transcriptomics and validates it against single-cell and tumor spatial data.
bioRxiv · Feb 13, 2026 · PreprintCancer Biology