Author

Sylvie André

Centre Hospitalier Universitaire Vaudois

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Jonathan BaciD· 2 shared Krisztián HomicskóiD· 2 shared Marina Alexandre Gaveta· 2 shared Raphaël GottardoiD· 2 shared Stephanie Tissot· 2 shared Antonia DigkliaiD· 1 shared Christel VoizeiD· 1 shared Christophe CisarovskyiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Jonathan BacORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

From Transcripts to Cells: Dissecting Sensitivity, Signal Contamination, and Specificity in Xenium Spatial Transcriptomics

Mariia Bilous, Daria Buszta, Jonathan Bac, Senbai Kang, Yixing Dong, Stephanie Tissot, Sylvie André, Marina Alexandre Gaveta, Christel Voize, Solange Peters, Krisztián Homicskó, Raphaël Gottardo

The paper evaluates Xenium spatial transcriptomics performance, identifies technical limitations, and introduces SPLIT to improve signal purity and cell-type resolution.

Nature Methods · Apr 30, 2026Peer-reviewedCancer Biology

Deciphering spatial heterogeneity of patient-derived organoids of colorectal tumors for drug discovery

Maxim N. Norkin, Jonathan Bac, Louis McConnell, Christophe Cisarovsky, Marina Alexandre Gaveta, Sylvie André, Simon Tanaka, Antonia Digklia, Sylke Hoehnel, Stephanie Tissot, Joerg Huelsken, Marianna Rapsomaniki, Raphaël Gottardo, Krisztián Homicskó

This study develops a platform to analyze spatial heterogeneity in colorectal tumor organoids using spatial transcriptomics and validates it against single-cell and tumor spatial data.

bioRxiv · Feb 13, 2026 · PreprintCancer Biology