Label-free Assessment of Complement-Dependent Cytotoxicity of Therapeutic Antibodies via a Whole-Cell MALDI Mass Spectrometry Bioassay
S. Schmidt, Alexander Geisel, Thomas Enzlein, Björn Fröhlich, Louise Pritchett, Mélanie Verneret, Christian Graf, Carsten Hopf
This study develops a label-free MALDI-TOF mass spectrometry bioassay to assess complement-dependent cytotoxicity of Rituximab, identifying metabolite markers and demonstrating robust concentration-response characteristics.
Scientific Reports · Sep 13, 2024Peer-reviewedBiochemistry