EGFR-Mediated Mechanotransduction in Aortic Valve Cells: A Key Pathway in Response to Wall Shear Stress
Amélie Gasté, Damien Marchese, Adèle Faucherre, Louna Lopez, Éric Bertrand, Alexis Théron, Marine Herbane, Amel Seddik, Chris Jopling, Jean-François Aviérinos, Hafid Ait‐Oufella, Valérie Deplano, Stéphane Zaffran
This study investigates how EGFR regulates wall shear stress-induced signaling in aortic valve cells and identifies its interaction with PIEZO1 in mechanotransduction.
bioRxiv · Mar 10, 2025 · PreprintDevelopmental Biology