Jean-François Aviérinos

EGFR-Mediated Mechanotransduction in Aortic Valve Cells: A Key Pathway in Response to Wall Shear Stress

This study investigates how EGFR regulates wall shear stress-induced signaling in aortic valve cells and identifies its interaction with PIEZO1 in mechanotransduction.

Clinical and Genetic insights in a tertiary care center cohort of patients with bicuspid aortic valve

The paper analyzes clinical and genetic factors in patients with bicuspid aortic valve to identify predictors of valve dysfunction and genetic pathways involved in degeneration.

Piezo1 is required for outflow tract and aortic valve development.

This study shows that PIEZO1 is essential for outflow tract and aortic valve development in zebrafish and identifies PIEZO1 variants linked to bicuspid aortic valve in humans.