This study investigates how EGFR regulates wall shear stress-induced signaling in aortic valve cells and identifies its interaction with PIEZO1 in mechanotransduction.

DOI 10.1101/2025.03.10.642402

mouseexperimental assay

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GeneticsInternational journal of cardiac imagingPeer-reviewedAug 10, 2021

Clinical and Genetic insights in a tertiary care center cohort of patients with bicuspid aortic valve

Alexis Théron, Anissa Touil, Noémie Resseguier…·Jean-François Aviérinos

The paper analyzes clinical and genetic factors in patients with bicuspid aortic valve to identify predictors of valve dysfunction and genetic pathways involved in degeneration.

7 citations

humanstatistical model

𝕏 PostBluesky

Developmental BiologybioRxivJan 23, 2019

Piezo1 is required for outflow tract and aortic valve development.

Adèle Faucherre, Hamid Moha ou Maati, Nathalie Nasr…·Chris Jopling

This study shows that PIEZO1 is essential for outflow tract and aortic valve development in zebrafish and identifies PIEZO1 variants linked to bicuspid aortic valve in humans.

87 citations

zebrafishexperimental assay

𝕏 PostBluesky