TM6SF2/PNPLA3/MBOAT7 loss-of-function genetic variants impact on NAFLD development and progression both in patients and in in vitro models
M. Longo, M. Meroni, Veronica Erconi, Fabrizia Carli, Chiara Macchi, Francesco Fortunato, Dario Ronchi, Silvia Sabatini, Erika Paolini, Emilia Rita De Caro, Anna Alisi, Luca Miele, Giorgio Soardo, Giacomo Pietro Comi, Luca Valenti, , Paola Dongiovanni
The paper investigates the combined effect of three genetic variants on NAFLD progression in patients and in vitro models, finding increased HCC risk and altered lipid and mitochondrial metabolism.
Digestive and Liver Disease · Feb 23, 2021Peer-reviewedGenetics