Antisense transcription can induce expression memory via stable promoter repression
Verena Mutzel, Till Schwämmle, Svearike Oeverdieck, Lucija Librenjak, Benedikt B. Boesen, Melissa Bothe, Rutger A. F. Gjaltema, Ilona Dunkel, Gemma Noviello, Edda G. Schulz
The paper shows that antisense transcription can create expression memory through promoter repression in mouse embryonic stem cells, with memory capacity increasing during differentiation.
Genome biology · Dec 20, 2025Peer-reviewedGenetics