Gemma Noviello

Transcription-dependent heterochromatin at the Xist promoter shapes the random choice of the inactive X chromosome

The paper identifies H3K9me3 accumulation at the Xist promoter as a transcription-dependent mechanism that influences random XCI choice in female cells.

Antisense transcription can induce expression memory via stable promoter repression

The paper shows that antisense transcription can create expression memory through promoter repression in mouse embryonic stem cells, with memory capacity increasing during differentiation.

HDAC3 prevents enhancer hyperactivation to enable developmental transitions

This study identifies HDAC3's role in preventing enhancer overactivation to regulate transcript dosage during developmental transitions.

Reporter CRISPR screens decipher cis- and trans-regulatory principles at the Xist locus

The paper uses CRISPR screens to identify transcription factors regulating Xist expression and their interactions with cis-regulatory elements during X-chromosome inactivation.

CasTuner: a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression

CasTuner enables analog tuning of endogenous gene expression using CRISPR/Cas systems and a degron domain, showing dose-dependent repression and application in studying gene dosage effects.

GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of a distal enhancer element

This study identifies GATA transcription factors as essential for initiating Xist upregulation and X-chromosome inactivation in mouse embryos through direct activation of a distal enhancer.

Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye development

This study identifies functional interactions between TGS1 and the Smn complex in Drosophila eye development, showing their roles in retinal progenitor cell viability and eye size.