Go/z-biased coupling profile of the dopamine D3 receptor
Lucrezia Zanetti, Luca Franchini, Shirsha Saha, Yini Liao, Brian S. Muntean, Cesare Orlandi
The paper investigates the G protein coupling profile of dopamine D3 receptor, finding it selectively activates Go and Gz subtypes but not Gi proteins, with structural determinants identified.
bioRxiv · Aug 8, 2025 · PreprintPharmacology & Toxicology