Replication stress at centromeres biases the segregation of DNA damage
Elena Di Tommaso, Luigi Fanelli, Simona Giunta
This study identifies a mechanism by which replication stress at centromeres leads to non-random segregation of DNA damage during mitosis, influenced by R-loops, Rad51 activity, and spindle dynamics.
bioRxiv · Sep 1, 2026 · PreprintCell Biology