Elena Di Tommaso

This study identifies a mechanism by which replication stress at centromeres leads to non-random segregation of DNA damage during mitosis, influenced by R-loops, Rad51 activity, and spindle dynamics.

The paper presents the first telomere-to-telomere diploid reference genome of the human embryonic stem cell line H9, revealing genomic features and ancestry.

The paper generates a complete diploid genome assembly for RPE-1 cells and uses it as a matched reference to improve multi-omics data analysis and identify haplotype-specific epigenetic variation.