Simona Giunta

This study identifies a mechanism by which replication stress at centromeres leads to non-random segregation of DNA damage during mitosis, influenced by R-loops, Rad51 activity, and spindle dynamics.

This paper presents the first fully phased, diploid, telomere-to-telomere genome of the zebra finch, revealing new genes and structural features.

This study investigates how variations in centromeric alpha-satellite array size affect centromere function during mitosis, finding that smaller arrays are more prone to missegregation and cohesion fatigue.

The paper characterizes human ectocentromeric sites as evolutionarily constrained and functionally heterogeneous elements along chromosome arms with context-dependent roles in chromatin state and transcription regulation.

The paper presents the first telomere-to-telomere diploid reference genome of the human embryonic stem cell line H9, revealing genomic features and ancestry.

The paper investigates how heterochromatin boundaries maintain centromere position, size, and number through specific histone modifications and methyltransferases.

The paper generates a complete diploid genome assembly for RPE-1 cells and uses it as a matched reference to improve multi-omics data analysis and identify haplotype-specific epigenetic variation.

The paper presents diploid genome assemblies for two human fibroblast cell lines, enabling clone-specific variant calling, improved read mapping, and accurate phasing.