EPOP and MTF2 Activate PRC2 Activity through DNA-sequence specificity
Jeffrey Granat, Sanxiong Liu, Luis Popoca, Ozgur Oksuz, Danny Reinberg
This study shows EPOP and MTF2 enhance PRC2's histone methyltransferase activity through DNA-sequence specific binding, promoting H3K27me3 deposition in collaboration with JARID2.
Proceedings of the National Academy of Sciences · Feb 6, 2026Peer-reviewedBiochemistry