Author

Jeffrey Granat

Howard Hughes Medical InstituteORCID 0000-0002-4626-6889Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Danny ReinbergiD· 2 shared Chul-Hwan LeeiD· 1 shared Gary LeRoyiD· 1 shared James Stafford· 1 shared Jia-Ray YuiD· 1 shared Luis Popoca· 1 shared Ozgur OksuziD· 1 shared Sanxiong LiuiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

Danny ReinbergORCID

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2 papers

Recent·Most cited

EPOP and MTF2 Activate PRC2 Activity through DNA-sequence specificity

Jeffrey Granat, Sanxiong Liu, Luis Popoca, Ozgur Oksuz, Danny Reinberg

This study shows EPOP and MTF2 enhance PRC2's histone methyltransferase activity through DNA-sequence specific binding, promoting H3K27me3 deposition in collaboration with JARID2.

Proceedings of the National Academy of Sciences · Feb 6, 2026Peer-reviewedBiochemistry

Automethylation of PRC2 fine-tunes its catalytic activity on chromatin

Chul-Hwan Lee, Jeffrey Granat, Jia-Ray Yu, Gary LeRoy, James Stafford, Danny Reinberg

This study identifies PRC2 automethylation on EZH1/2 and SUZ12 as a self-activating mechanism that regulates its catalytic activity on chromatin.

bioRxiv · Jun 17, 2018 · PreprintBiochemistry