Danny Reinberg

PDS5A and TOP2B cooperate for chromatin recruitment via CTCF

This study identifies a functional interaction between PDS5A and TOP2B at CTCF-bound chromatin sites, showing their cooperative recruitment and impact on gene expression and chromatin structure in gliomas.

FBRSL1 couples ncPRC1.3 to CoREST to repress cell-cycle genes during human neuronal differentiation

This study shows FBRSL1 couples ncPRC1.3 to CoREST for transcriptional repression during neuronal differentiation, contrasting AUTS2's activating role.

E3 Ligase Ligandalyzer: A Structure-First, Ligand-Centric Platform for E3 Ligase Recruiter Selection

E3 Ligase Ligandalyzer provides a platform for exploring E3 ligase-recruiter complexes, enabling analysis of chemical and structural data to support degrader design.

A Lineage-Specific Peptide Suppresses Juvenile Hormone to Drive Reproductive and Longevity Reprogramming in Ants

The paper identifies HCRG1, a peptide that suppresses juvenile hormone to enable reproductive and longevity changes in ants.

Targeting an RNA Editor to Impede H3K27M+ Pediatric Gliomas

This study identifies ADAR as a key mediator of immune evasion in H3K27M+ pediatric gliomas and shows that ATRA can induce ADAR degradation, enhancing antiviral responses and tumor immunogenicity.

EPOP and MTF2 Activate PRC2 Activity through DNA-sequence specificity

This study shows EPOP and MTF2 enhance PRC2's histone methyltransferase activity through DNA-sequence specific binding, promoting H3K27me3 deposition in collaboration with JARID2.

CTCF-RNA interactions orchestrate cell-specific chromatin loop organization

This study shows that CTCF-ZF1 RNA interactions are essential for maintaining cell-type-specific chromatin loops during differentiation, with disruption leading to gene dysregulation and loop loss.

Members of an array of zinc finger proteins specify distinct Hox chromatin boundaries

The paper identifies zinc finger proteins that establish distinct chromatin boundaries at Hox clusters during development, working with cohesin to regulate cell fate.

SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex

This study identifies SIRT1's role in regulating DNA damage signaling via interaction with the PP4 phosphatase complex, showing SIRT1 inhibits PP4 to modulate key DDR markers.

Gain and loss of function variants in EZH1 disrupt neurogenesis timing and cause overlapping neurodevelopmental disorders

Inheritance of Repressed Chromatin Domains during S-phase Requires the Histone Chaperone NPM1

The paper shows that NPM1 is essential for the inheritance of repressed chromatin domains during DNA replication in mouse embryonic stem cells.

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription

The paper identifies LEDGF and HDGF2 as proteins that substitute for FACT in differentiated tissues to enable RNAPII to overcome nucleosome barriers during transcription.

RNA interactions with CTCF are essential for its proper function

The paper shows that CTCF's RNA-binding ability is crucial for its chromatin association and insulation function.

Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma

The paper investigates how H3K27M mutations inhibit PRC2 in DIPG, revealing mechanisms of chromatin alteration and PRC2 dysfunction.

Automethylation of PRC2 fine-tunes its catalytic activity on chromatin

This study identifies PRC2 automethylation on EZH1/2 and SUZ12 as a self-activating mechanism that regulates its catalytic activity on chromatin.

Capturing the onset of PRC2-mediated repressive domain formation

The paper demonstrates a two-step mechanism of PRC2-mediated repressive domain formation through nucleation sites and long-range spreading of H3K27me2/3.

ChIPSeqSpike: A R/Bioconductor package for ChIP-Seq data scaling according to spike-in control

ChIPSeqSpike provides tools for normalizing, assessing, and analyzing ChIP-Seq data using spike-in controls, producing scaled bigwig files and scaling factors.

Olfactory Receptors Are Required For Social Behavior And Neural Plasticity In Ants, As Evidenced By CRISPR-Mediated Gene Knockout

This study uses CRISPR to knock out the Orco gene in ants, showing its role in olfaction, social behavior, and neural plasticity.