Ozgur Oksuz

This study shows EPOP and MTF2 enhance PRC2's histone methyltransferase activity through DNA-sequence specific binding, promoting H3K27me3 deposition in collaboration with JARID2.

The paper identifies RNA-binding as a common feature of transcription factors, showing it contributes to gene regulation and is conserved in vertebrates.

The paper identifies LEDGF and HDGF2 as proteins that substitute for FACT in differentiated tissues to enable RNAPII to overcome nucleosome barriers during transcription.

The paper investigates how H3K27M mutations inhibit PRC2 in DIPG, revealing mechanisms of chromatin alteration and PRC2 dysfunction.

The paper demonstrates a two-step mechanism of PRC2-mediated repressive domain formation through nucleation sites and long-range spreading of H3K27me2/3.