Author

Luisa Henkel

German Cancer Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Benedikt RauscheriD· 3 shared Michael BoutrosiD· 3 shared Florian HeigweriD· 2 shared Barbara A. SchmittiD· 1 shared Jan Winter· 1 shared Oksana VoloshanenkoiD· 1 shared Thomas HielscheriD· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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3 shared papersSystems Biology

Benedikt RauscherORCID

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3 papers

Recent·Most cited

Pooled CRISPR screening at high sensitivity with an empirically designed sgRNA library

Luisa Henkel, Benedikt Rauscher, Barbara A. Schmitt, Jan Winter, Michael Boutros

This study designs an empirically optimized sgRNA library and experimental protocol to enhance the sensitivity and dynamic range of CRISPR screens for gene essentiality.

BMC Biology · Nov 23, 2020Peer-reviewedGenomics

Lineage specific core-regulatory circuits determine gene essentiality in cancer cells

Benedikt Rauscher, Luisa Henkel, Florian Heigwer, Michael Boutros

The paper identifies lineage-specific core-regulatory circuits in cancer cells and shows their role in gene essentiality and therapeutic vulnerability.

bioRxiv · Apr 16, 2019 · PreprintSystems Biology

Towards an Integrated Map of Genetic Interactions in Cancer Cells

Benedikt Rauscher, Florian Heigwer, Luisa Henkel, Thomas Hielscher, Oksana Voloshanenko, Michael Boutros

The paper develops MINGLE, a computational framework to integrate CRISPR/Cas9 screens and identify genetic interactions in cancer cells, revealing new vulnerabilities and building a large genetic network.

Molecular Systems Biology · Feb 1, 2018Peer-reviewedSystems Biology