Author

Luiza M Gruel Budet

National Institutes of Health

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Daniel M. RamosiD· 1 shared Derek P. NarendraiD· 1 shared James HawrotiD· 1 shared Jennifer D. PeterseniD· 1 shared Julia A. ThayeriD· 1 shared Michael Emmerson WardiD· 1 shared Shiori SekineiD· 1 shared Xiaoping HuangiD· 1 shared

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1 shared paperCell Biology

Daniel M. RamosORCID

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1 paper

Recent·Most cited

Cell BiologyThe EMBO JournalPeer-reviewedNov 20, 2025

✦ In-depth digest

Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate

Julia A. Thayer, Jennifer D. Petersen, Xiaoping Huang…·Derek P. Narendra

A HaloTagged MFN2 reporter enabled CRISPRi screens showing diverse mitochondrial damage activates PINK1-Parkin via membrane potential loss, with TOM retaining PINK1 when TIM23 is blocked.

32 citationstop 1%

humanCRISPR screen

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