Author

Xiaoping Huang

National Institutes of HealthORCID 0000-0002-6826-0322Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Derek P. NarendraiD· 2 shared Jennifer D. PeterseniD· 2 shared Alexandra J Gilsrud· 1 shared Angelo MadrugaiD· 1 shared Daniel M. RamosiD· 1 shared Drew R. JonesiD· 1 shared Hsin-Pin Lin· 1 shared James HawrotiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Derek P. NarendraORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cell BiologyThe EMBO JournalPeer-reviewedNov 20, 2025

✦ In-depth digest

Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate

Julia A. Thayer, Jennifer D. Petersen, Xiaoping Huang…·Derek P. Narendra

A HaloTagged MFN2 reporter enabled CRISPRi screens showing diverse mitochondrial damage activates PINK1-Parkin via membrane potential loss, with TOM retaining PINK1 when TIM23 is blocked.

32 citationstop 1%

humanCRISPR screen

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ImmunologybioRxivPreprintJan 23, 2025

The expression of IL-35 in the prophase of liver failure and its preliminary exploration for the mechanism of immunoregulation by IL-35 and glucocorticoids

Yan Wang, Xin-chi Zhang, Yu-fan Xiong…·Jing Gan

The paper determines the optimal dose of concanavalin for a liver failure mouse model and investigates the role of IL-35 and glucocorticoids in immunoregulation and disease progression.

DOI 10.1101/2025.01.23.634472

mouseproteomics

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Cell BiologyThe EMBO JournalPeer-reviewedOct 8, 2024

DELE1 promotes translation-associated homeostasis, growth, and survival in mitochondrial myopathy

Hsin-Pin Lin, Jennifer D. Petersen, Alexandra J Gilsrud…·Derek P. Narendra

The paper identifies DELE1's role in promoting translation-associated homeostasis, growth, and survival in mitochondrial myopathy through the mt-ISR pathway.

28 citations

mouseproteomics

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