Author
National Institutes of HealthORCID 0000-0001-8050-8274Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Matthew Nolan, Sandeep Aryal, I. Sandra Ndayambaje…·Clotilde Lagier‐Tourenne
The paper shows statins and mevalonate pathway inhibition increase STMN2 and ATF3, promoting neuronal regeneration in neurodegenerative disease.
Julia A. Thayer, Jennifer D. Petersen, Xiaoping Huang…·Derek P. Narendra
A HaloTagged MFN2 reporter enabled CRISPRi screens showing diverse mitochondrial damage activates PINK1-Parkin via membrane potential loss, with TOM retaining PINK1 when TIM23 is blocked.
Veronica H. Ryan, Sydney Lawton, Joel F. Reyes…·Michael Emmerson Ward
The paper identifies BORC as a modifier of TDP-43 protein levels in neurons, showing lysosome transport is required for TDP-43 turnover.
Sahba Seddighi, Yue Andy Qi, Anna‐Leigh Brown…·Michael Emmerson Ward
The paper shows that loss of TDP-43 function leads to the expression of de novo proteins from mis-spliced mRNA transcripts in ALS/FTD.
João D. Pereira, Daniel M. DuBreuil, Anna‐Claire Devlin…·Brian J. Wainger
The paper develops a cultured sensorimotor organoid model that forms functional neuromuscular junctions and uses it to study ALS subgroups.