Author

Luka Simsive

University of Helsinki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1

Frequent Co-Authors

Vivek SharmaiD· 3 shared Oleksii ZdorevskyiiD· 2 shared Alison ParkiniD· 1 shared Amina DjurabekovaiD· 1 shared Ashleigh KroppiD· 1 shared Benjamin G Hartmann· 1 shared Chris GreeningiD· 1 shared Christopher K. BarlowiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

Vivek SharmaORCID

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3 papers

Recent·Most cited

Fast prediction of acidic amino acid sidechain conformations for cryo-EM modeling

Georgios Kolypetris, Amina Djurabekova, Jonathan Lasham, Luka Simsive, Janet Vonck, Vivek Sharma

The paper develops a workflow to predict sidechain conformations of acidic amino acids in cryo-EM maps, validated through Q-score and molecular dynamics simulations.

bioRxiv · Jul 14, 2026 · PreprintBiophysics

Quinone-transporting filaments extend the respiratory chain of Gram positive bacteria

Ashleigh Kropp, Kazem Asadollahi, Jamie A Stapleton, Luka Simsive, Pok Man Leung, Rachel L. Darnell, Christopher K. Barlow, Benjamin G Hartmann, Nicholas D. J. Yates, Daniel Fox, Chris Greening, Oleksii Zdorevskyi, Vivek Sharma, James N. Blaza, Alison Parkin, Rhys Grinter

This study identifies quinone-transporting filaments in Bacillus subtilis as an alternative to membrane invaginations for expanding respiratory capacity in Gram-positive bacteria.

bioRxiv · Jun 27, 2026 · PreprintBiochemistry

Proton transfer through a charged conduit in respiratory complex I - long range effects and conformational gating

Luka Simsive, Oleksii Zdorevskyi, Vivek Sharma

The paper uses QM/MM simulations to study proton transfer through the E channel in complex I, identifying energetically favorable paths and a gating role for a conserved tyrosine residue.

Journal of Chemical Information and Modeling · Sep 18, 2025Peer-reviewedBiochemistry