Christopher K. Barlow

Generation of a novel Slc7a9G105R mutant mouse identifies new biomarkers for cystinuria

This paper generates a novel Slc7a9G105R mouse model to study cystinuria, identifying new biomarkers and therapeutic insights.

Quinone-transporting filaments extend the respiratory chain of Gram positive bacteria

This study identifies quinone-transporting filaments in Bacillus subtilis as an alternative to membrane invaginations for expanding respiratory capacity in Gram-positive bacteria.

A mixer tap mechanism in Mycobacterium tuberculosis regulates a critical metabolic node in response to nutrient availability

The paper identifies a regulatory mechanism in Mycobacterium tuberculosis that controls metabolic flux through coordinated enzyme abundance and metabolite effects, likened to a mixer tap.

Non-enzymatic assimilation of organosulfur compounds at the interface of geochemistry and biochemistry

This study shows that microbial assimilation of DMS and DMSO can occur through non-enzymatic oxidative mechanisms driven by light and heat, producing methanesulfonic acid and sulfite.

A metabolic atlas of the Klebsiella pneumoniae species complex reveals lineage-specific metabolism that supports co-existence of diverse lineages

This study maps metabolic diversity in Klebsiella pneumoniae sub-lineages using genomics and metabolic modeling, revealing lineage-specific metabolic profiles that support coexistence through cross-feeding.

Valine restriction extends survival in a Drosophila model of short-chain enoyl-CoA hydratase 1 (ECHS1) deficiency

This study establishes a Drosophila model of ECHS1 deficiency and shows that valine restriction improves larval survival.

A defined diet for pre-adult Drosophila melanogaster

This paper introduces an adjusted diet formula for Drosophila melanogaster larvae to improve growth, development, and survival, with applications in studying metabolic disorders.

Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy.

This study shows sodium selenate reduces seizures, cognitive dysfunction, and sensorimotor deficits in a rat model of chronic drug-resistant temporal lobe epilepsy.