CD8+ T cells regulate the bioenergetic reprogramming of lymphoid organs and the heart during viral infection
Laura Antonio-Herrera, Cécile Philippe, Attila Kiss, Hatoon Baazim, Juan Sanchez, Henrique G. Colaço, Felix Clemens Richter, Joel Xu En Wong, Fabian Amman, Magdalena Siller, Hao Wu, Sophia M. Hochrein, Stefanie Ponti, Victoria Weissenböck, Thomas Wanek, , Andreas Bergthaler
This study shows CD8+ T cells drive energy substrate redistribution between lymphoid organs and the heart during viral infection, with metabolic adaptations affecting cardiac function.
bioRxiv · Aug 20, 2025 · PreprintImmunology