Anna Hofmann

Gut-derived ammonia modulates hypothalamic stress responses during viral infection

This study shows that gut-derived ammonia modulates hypothalamic stress responses during viral infection by increasing corticosterone levels and affecting antiviral responses.

CD8+ T cells regulate the bioenergetic reprogramming of lymphoid organs and the heart during viral infection

This study shows CD8+ T cells drive energy substrate redistribution between lymphoid organs and the heart during viral infection, with metabolic adaptations affecting cardiac function.

Crosstalk between CD8+ T cells and systemic bile acid metabolism controls LCMV-induced immunopathology

This study shows that CD8+ T cells and bile acid metabolism interact during LCMV infection, with bile acids affecting T cell responses and immunopathology.

Purine nucleobases enhance CD8+ T cell effector function

This study identifies purine nucleobases as immunometabolites that enhance CD8+ T cell effector function by enabling a metabolic switch from de novo synthesis to salvage pathway.