Glioblastoma Invasion Remodels Neural Circuits and Drives Persistent GABAergic Dysfunction in Human Brain Organoids
Ewa Beata Grassin, Himanshu Chintalapudi, Xianjun Dong, David S Goldman, Danielle Hagee, Chunxiao Cui, Aaron J. Goldman, Luke Lee
This study uses human brain organoids to show that glioblastoma invasion disrupts GABAergic neurons, causing persistent chloride imbalance and dysfunction, even after chemotherapy.
bioRxiv · Aug 12, 2026 · PreprintCancer Biology