Xianjun Dong

Melanoma germline genetics: immune, cancer driver, and Wnt signaling genes

This paper identifies 116 risk loci for melanoma through GWAS, links susceptibility to immunity and Wnt signaling, and develops a PRS improving risk prediction.

Glioblastoma Invasion Remodels Neural Circuits and Drives Persistent GABAergic Dysfunction in Human Brain Organoids

This study uses human brain organoids to show that glioblastoma invasion disrupts GABAergic neurons, causing persistent chloride imbalance and dysfunction, even after chemotherapy.

Single cell eQTL mapping reveals convergent glial-neuronal risk architecture in Parkinson's disease

The paper fine-maps PD GWAS signals across cell types, revealing convergent glial-neuronal risk genes and a shared vesiculopathy network.

Experimental and Computational Methods for Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data

This paper develops computational tools for allelic imbalance analysis using single-nucleus RNA-seq and demonstrates their application in a Parkinson's disease cohort.

Integrating Long-Read Structural Variant Analysis with single-nucleus RNA-seq to Elucidate Gene Expression Effects in Disease

This study integrates long-read WGS and single-nucleus RNA-seq to identify structural variants affecting gene expression in Parkinson's disease with cell type resolution.

A Reference Atlas of the Human Dorsal Root Ganglion

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

EVscope: A Comprehensive Bioinformatics Pipeline for Accurate and Robust Analysis of Total RNA Sequencing from Extracellular Vesicles

EVscope is a bioinformatics pipeline for analyzing EV RNA-seq data, improving read assignment and contamination correction with a comprehensive annotation and visualization tool.

An integrative systems-biology approach defines mechanisms of Alzheimer's disease neurodegeneration

This study integrates multi-omics data from Drosophila and human Alzheimer's disease models to identify pathways involved in neurodegeneration.

Transcriptional pathobiology and multi-omics predictors for Parkinson's disease

This study identifies 1,111 PD-associated RNAs in blood and develops a multi-omics model with AUC 0.89 for PD diagnosis, offering insights into pathobiology and potential clinical applications.

Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model

This study creates a Drosophila tauopathy model with the P251L mutation and uses single-cell RNA sequencing to identify molecular changes in neuronal and glial cells.

Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging

The paper identifies a conserved role for APP in proteostasis during aging through genetic and multi-omics analyses in Drosophila and human models.

Detecting Full-Length EccDNA with FLED and long-reads sequencing

The paper introduces FLED, a method combining rolling circle amplification and nanopore sequencing to detect full-length eccDNAs, identifying over 5,000 per sample in human cell lines.

Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease

This study identifies circRNAs specific to dopamine and pyramidal neurons and links them to neuropsychiatric diseases.

Discovery of genomic loci associated with sleep apnoea risk through multi-trait GWAS analysis with snoring

This study identifies 49 genetic loci associated with sleep apnoea risk using multi-trait GWAS, with 29 replicated in a large cohort, and finds genetic correlations with several complex traits.

powerEQTL: An R package and shiny application for sample size and power calculation of bulk tissue and single-cell eQTL analysis

The paper introduces powerEQTL, an R package and web tool for calculating sample size and power for bulk and single-cell eQTL analysis.