Compartmental Profiling of PDE4B in Systemic Sclerosis
Astrid Hofman, Pietro Bearzi, Sara Burckhardt, Maryam Asadikorayam, Andrea Laimbacher, Cristian Iperi, Muriel Elhaï, Cosimo Bruni, Flurin Sturzenegger, Shervin Assassi, Laura Much, Anna‐Maria Hoffmann‐Vold, Blaž Burja, Helen C. Jarnigan, Michael L. Whitfield, , Oliver Distler
This study characterizes PDE4B expression in systemic sclerosis (SSc) tissues, showing dysregulation in immune cells and protein enrichment in activated fibroblasts, supporting PDE4B as a therapeutic target.
bioRxiv · Jul 28, 2026 · PreprintMolecular Biology