Shervin Assassi

Compartmental Profiling of PDE4B in Systemic Sclerosis

This study characterizes PDE4B expression in systemic sclerosis (SSc) tissues, showing dysregulation in immune cells and protein enrichment in activated fibroblasts, supporting PDE4B as a therapeutic target.

Deletion of adipocyte Sine Oculis Homeobox Homolog 1 prevents lipolysis and attenuates skin fibrosis.

This study identifies SIX1 as a driver of dermal fibrosis in systemic sclerosis by linking its upregulation to adipocyte dysfunction and fibrotic gene expression.

Three Distinct Transcriptional Profiles of Monocytes Correlate with Disease Activity in SSc Patients

This study identifies three monocyte transcriptional subgroups in SSc patients that correlate with disease activity, particularly lung function.