Error-free and efficient prime editing in absence of maternal Polθ
François Kroll, Malo Serafini, Luna de Barbarin, José Roberto Alvarez Vargas, Julie Thanh-Mai Dang, Marion Rosello, Marie As, Anne De Cian, Jean‐Paul Concordet, Carine Giovannangeli, Filippo Del Bene
This study identifies that loss of Polθ reduces unwanted mutations in zebrafish prime editing, enabling error-free and efficient genome editing.
bioRxiv · May 13, 2026 · PreprintGenetics