François Kroll

This study identifies that loss of Polθ reduces unwanted mutations in zebrafish prime editing, enabling error-free and efficient genome editing.

JACUZI-SD is a method to induce sleep deprivation in larval zebrafish with minimal stress, reducing total sleep time by 41-64% and eliciting rebound sleep.

This study shows that srrm3 regulates arousal states in zebrafish via cAMP signaling, with mutations causing hyperarousal and transcriptional changes.

This study demonstrates that CRISPR-CasRx reduces C9orf72 repeat RNAs and DPRs in vitro and in vivo, suggesting its therapeutic potential for ALS/FTD.

The paper identifies two micropeptides encoded by lincRNAs that regulate chromatin accessibility in vertebrate-specific neural cells and show their role in brain development.

The paper shows that small-molecule ketone esters reduce epileptiform discharges and improve cognition in an Alzheimer's disease mouse model.

This paper introduces a CRISPR-Cas9 method for rapid generation of F0 biallelic knockouts in zebrafish, enabling quick screening of complex phenotypes.

This study shows that a ketogenic diet and beta-hydroxybutyrate reduce epileptiform spikes, improve memory, and increase survival in Alzheimer's mouse models.