Excavating Podocyte-Protective Targets of phloroglucinol-terpene hybrids Utilizing AI Models and Omics Analysis
Ting Chen, Xiaoyan Liu, Juan Li Zhu, Xinting Zhang, Jianhui Zhang, Hongping Yu, Ziyan Zoe Xu, Dingyan Wang, Yao‐Bin Zhu, Feisheng Zhong, Luo Jiewei
This study identifies R14, a phloroglucinol-terpene hybrid, as a novel EGFR inhibitor that protects podocytes from apoptosis through modulation of the PI3K/AKT/mTOR pathway.
bioRxiv · Feb 22, 2025 · PreprintCell Biology