Feisheng Zhong

This study identifies R14, a phloroglucinol-terpene hybrid, as a novel EGFR inhibitor that protects podocytes from apoptosis through modulation of the PI3K/AKT/mTOR pathway.

EquiScore is a protein-ligand interaction scoring method that outperforms existing methods on external test sets and shows potential for lead compound optimization.

This paper develops a deep learning system to design multitarget antipsychotic drugs, generating novel compounds with activity against multiple receptors and demonstrating efficacy in animal models.

The paper introduces a Siamese spectral-based graph convolutional network to infer protein targets of chemical compounds from gene expression data, achieving better performance than existing methods.