Dingyan Wang

OriGene identifies therapeutic targets by integrating diverse data modalities and outperforms human experts and models in accuracy and robustness.

This study identifies R14, a phloroglucinol-terpene hybrid, as a novel EGFR inhibitor that protects podocytes from apoptosis through modulation of the PI3K/AKT/mTOR pathway.

The paper introduces a Siamese spectral-based graph convolutional network to infer protein targets of chemical compounds from gene expression data, achieving better performance than existing methods.