AT1R-Selective Negative Allosteric Modulator Targeting the Epitope for Pathogenic Autoantibody Activation
Khuraijam Dhanachandra Singh, Triveni R. Pardhi, Terri J. Harford, Luxmichan Laishram, Tarun Ravi, Russell W. Desnoyer, Anjli P. Maroo, W.H. Wilson Tang, Sadashiva S. Karnik
This paper develops TP1, an AT1R-selective negative allosteric modulator that blocks autoantibody binding and preserves orthosteric functions, showing therapeutic potential for autoimmune conditions.
bioRxiv · Oct 13, 2026 · PreprintPharmacology & Toxicology