Author

Khuraijam Dhanachandra Singh

Cleveland ClinicORCID 0000-0003-0506-6896Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Russell W. DesnoyeriD· 2 shared Sadashiva S. KarnikiD· 2 shared Tarun RaviiD· 2 shared Terri J. HarfordiD· 2 shared Triveni R. PardhiiD· 2 shared Ajay H. ZalavadiaiD· 1 shared Anjli P. MarooiD· 1 shared Kate T. StensoniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersPharmacology & Toxicology

Russell W. DesnoyerORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintOct 13, 2026

AT1R-Selective Negative Allosteric Modulator Targeting the Epitope for Pathogenic Autoantibody Activation

Khuraijam Dhanachandra Singh, Triveni R. Pardhi, Terri J. Harford…·Sadashiva S. Karnik

This paper develops TP1, an AT1R-selective negative allosteric modulator that blocks autoantibody binding and preserves orthosteric functions, showing therapeutic potential for autoimmune conditions.

DOI 10.64898/2026.10.12.758523

humanexperimental assay

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PathologybioRxivPreprintJan 29, 2025

Microbial metabolite 4-ethylphenylsulfate (4EPS) interacts with AT1R, reduces blood pressure and outcome of AngII-induced aortic aneurysm

Terri J. Harford, Khuraijam Dhanachandra Singh, Triveni R. Pardhi…·Sadashiva S. Karnik

This study shows that 4-ethylphenylsulfate (4EPS) interacts with AT1R, lowers blood pressure, and reduces aortic aneurysm severity in mice.

DOI 10.1101/2025.01.29.635371

mouseproteomics

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