Suppression of interferon signaling via small molecule modulation of TFAM
Dionisia P. Sideris, Hsuan Lee, Lyndsay Olson, Kalyan C. Nallaparaju, Keiichiro Okuyama, Jeff Ciavarri, Robert Lafyatis, Mads Breum Larsen, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Toren Finkel, Yuan Liu, Bill B. Chen, Lin Lyu
This study identifies small molecule modulators of TFAM that increase its levels and mtDNA copy number, reducing mtDNA stress and inflammation in disease models.
eLife · Feb 6, 2026Peer-reviewedCell Biology