Author

Mads Breum Larsen

University of PittsburghORCID 0000-0001-5361-0898Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Assay:imaging· 1 Assay:metabolomics· 1

Frequent Co-Authors

Bill B. CheniD· 2 shared Bennett Van HouteniD· 1 shared Bingjie WangiD· 1 shared Bo LiniD· 1 shared Bokai ZhuiD· 1 shared Chris L. DupontiD· 1 shared Daniel P. CamarcoiD· 1 shared Dionisia P. Sideris· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

Bill B. ChenORCID

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2 papers

Recent·Most cited

Cell BiologyeLifePeer-reviewedFeb 6, 2026

Suppression of interferon signaling via small molecule modulation of TFAM

Dionisia P. Sideris, Hsuan Lee, Lyndsay Olson…·Lin Lyu

This study identifies small molecule modulators of TFAM that increase its levels and mtDNA copy number, reducing mtDNA stress and inflammation in disease models.

DOI 10.7554/elife.108742.2

humanproteomics

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Cell BiologyNature CommunicationsPeer-reviewedAug 5, 2025

SON-dependent nuclear speckle rejuvenation alleviates proteinopathies

William A. Dion, Yuren Tao, Maci Chambers…·Bokai Zhu

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.

19 citationstop 5%

humanmouse

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