Bill B. Chen

This study identifies small molecule modulators of TFAM that increase its levels and mtDNA copy number, reducing mtDNA stress and inflammation in disease models.

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.

This paper uses CRISPR-edited human iPSCs with hypomorphic NOTCH1 to model hypoplastic left heart syndrome, identifying auranofin as a potential therapeutic.