Obesity-Driven Lung Lipidome Remodeling Suppresses NK Cell Activation and Antiviral Immunity to Influenza Infection
Pamela H. Brigleb, M B Frank, Lauren Rowland, Theresa Bub, Cliff S. Guy, Brandi Livingston, Alexandra H. Mandarano, Emily R. Sekera, John J. Bowling, Stacey Schultz‐Cherry
This study shows obesity remodels the lung lipidome, impairing NK cell function and antiviral immunity against influenza, and demonstrates that weight loss can restore these functions.
bioRxiv · Mar 7, 2026 · PreprintMicrobiology