Pamela H. Brigleb

This study shows obesity remodels the lung lipidome, impairing NK cell function and antiviral immunity against influenza, and demonstrates that weight loss can restore these functions.

This study shows that H5N1 clade 2.3.4.4b influenza virus can infect mice via intraductal inoculation, suggesting a potential new transmission route and a model for studying mammary gland infections.

This study compares the replication ability of avian and mammalian-derived clade 2.3.4.4b H5N1 viruses in epithelial cells from different species, finding that mammalian strains replicate more broadly.

The paper shows that pre-existing immunity from H1N1 infection or vaccination can protect against lethal HPAI H5N1 clade 2.3.4.4b challenge in mice and ferrets, independent of hemagglutination inhibition titers.

This study investigates the effects of oral exposure to pasteurized HPAI H5N1 virus in milk on immune response and mortality in mice, finding limited health risk and no prevention of immune-mediated protection.