Author

Cliff S. Guy

St. Jude Children's Research HospitalORCID 0000-0001-7486-7107Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Alev BaysoyiD· 1 shared Alexandra H. MandaranoiD· 1 shared Allister J. LoughraniD· 1 shared Archibald EnninfuliD· 1 shared Benjamin R. TreatiD· 1 shared Beth ManniD· 1 shared Bo Tao· 1 shared Brandi Livingston· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperGenomics

Alev BaysoyORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MicrobiologybioRxivPreprintMar 7, 2026

Obesity-Driven Lung Lipidome Remodeling Suppresses NK Cell Activation and Antiviral Immunity to Influenza Infection

Pamela H. Brigleb, M B Frank, Lauren Rowland…·Stacey Schultz‐Cherry

This study shows obesity remodels the lung lipidome, impairing NK cell function and antiviral immunity against influenza, and demonstrates that weight loss can restore these functions.

DOI 10.64898/2026.03.06.710186

mouseproteomics

𝕏 PostBluesky

MicrobiologybioRxivPreprintFeb 8, 2025

Anaerobic Fluorescent Reporters Enable In Vivo Tracking of VRE Dynamics in Enterococcus faecium

Benjamin R. Treat, Joseph Hobeika, Milisen Tvarkunas…·Elisa B. Margolis

This paper develops anaerobic fluorescent reporters and genetic tools to track VREfm colonization dynamics in the gut, overcoming resistance and oxygen dependency issues.

DOI 10.1101/2025.02.08.637206

mouseproteomics

𝕏 PostBluesky

GenomicsbioRxivPreprintNov 18, 2024

✦ In-depth digest

Spatially Resolved in vivo CRISPR Screen Sequencing via Perturb-DBiT

Alev Baysoy, Xiaolong Tian, Feifei Zhang…·Rong Fan

Perturb-DBiT co-sequences spatial transcriptomes and gRNAs on one tissue section, supporting genome-wide in vivo CRISPR screens in FFPE and fresh-frozen tumors across three cancer models.

45 citations

mousehuman

𝕏 PostBluesky

NeurosciencebioRxivPreprintOct 19, 2021

Fetal neural progenitors process TLR signals from bacterial components to enhance proliferation and rework brain development

Beth Mann, Jeremy Chase Crawford, Kavya Reddy…·ELAINE I. TUOMANEN

The paper shows bacterial PAMPs activate TLR2/6 on fetal NPCs, enhancing proliferation and altering brain development in mice.

DOI 10.1101/2021.10.19.464985

mousebulk RNA-seq

𝕏 PostBluesky