Mégane Lemaître

This study shows that axonopathy in DMD limits microdystrophin gene therapy efficacy by demonstrating that dystrophin is expressed in peripheral nerves and its absence causes nerve structural collapse and impaired nerve-muscle connectivity.

This study shows that GDF5 overexpression in DMD mdx mice improves muscle histology, reduces inflammation, and enhances microdystrophin gene therapy outcomes.

This study identifies CaVβ1 isoforms involved in neuromuscular junction formation and maintenance through developmental regulation and functional analysis.

This study compares the effects of endurance and resistance exercise on OPMD skeletal muscle in mice, finding that resistance exercise reduces PABPN1 aggregates and reverses muscle atrophy, while endurance exercise increases aggregates and collagen deposition.

This study identifies Vangl2 as a regulator of MuSK signaling in neuromuscular synapse formation, showing its role in AChR accumulation and NMJ stability.