Author

Sestina Falcone

InsermORCID 0000-0002-3574-0602Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Aly BourguibaiD· 4 shared Christel GentiliD· 4 shared France Piétri‐RouxeliD· 4 shared Zoheir GuesmiaiD· 4 shared Lucile SaillardiD· 3 shared Mégane Lemaître· 3 shared Pierre MeunieriD· 3 shared Amélie VergnoliD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersPhysiology

Aly BourguibaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Axonopathy in Duchenne Muscular Dystrophy limits microdystrophin gene therapy efficacy

Aly Bourguiba, Maxime Gelin, Aurélie Fail, Lucile Saillard, Stéphanie Bauché, Cécile Peccate, Pierre Meunier, Zoheir Guesmia, Lou Ann Mirabile, Julianne Perronnet, Mégane Lemaître, Lorenzo Giordani, Sestina Falcone, Christel Gentil, France Piétri‐Rouxel

This study shows that axonopathy in DMD limits microdystrophin gene therapy efficacy by demonstrating that dystrophin is expressed in peripheral nerves and its absence causes nerve structural collapse and impaired nerve-muscle connectivity.

bioRxiv · Aug 20, 2026 · PreprintPhysiology

GDF5 modulation of MuSC pool as a potential therapeutic benefit for DMD

Christel Gentil, Aly Bourguiba, Amélie Vergnol, Bruno Cadot, Zoheir Guesmia, Lucile Saillard, Pierre Meunier, Bénédicte Hoareau‐Coudert, Mégane Lemaître, Sestina Falcone, Lorenzo Giordani, France Piétri‐Rouxel

This study shows that GDF5 overexpression in DMD mdx mice improves muscle histology, reduces inflammation, and enhances microdystrophin gene therapy outcomes.

Molecular Therapy — Nucleic Acids · Jul 7, 2026Peer-reviewedCell Biology

GDF5 as a Multimodal Protector of the Motor Unit in Amyotrophic Lateral Sclerosis

Aly Bourguiba, Sonia Pezet, Massiré Traoré, Christel Gentil, Thibaut Marais, Aurélie Fail, Maxime Gelin, Julien Messéant, Pierre Meunier, Sofia Benkhelifa‐Ziyyat, Zoheir Guesmia, Bruno Cadot, Antonio Musarò, Gabriella Dobrowolny, Julianne Perronnet, , France Piétri‐Rouxel

This study identifies GDF5 as a protective factor in ALS by restoring SMAD signaling and preserving motor unit integrity through gene delivery in a mouse model.

bioRxiv · Jul 3, 2026 · PreprintPhysiology

Identification of CaVβ1 isoforms required for neuromuscular junction formation and maintenance

Amélie Vergnol, Aly Bourguiba, Stéphanie Bauché, Massiré Traoré, Gelin Maxime, Christel Gentil, Sonia Pezet, Lucile Saillard, Meunier Pierre, Mégane Lemaître, Perronnet Julianne, Frédéric Torès, Candice Gautier, Zoheir Guesmia, Eric Allemand, , Sestina Falcone

This study identifies CaVβ1 isoforms involved in neuromuscular junction formation and maintenance through developmental regulation and functional analysis.

Cells · Aug 6, 2025Peer-reviewedPhysiology