MYC is sufficient to generate mid-life high-grade serous ovarian and uterine serous carcinomas in a p53-R270H mouse model
A. Blackman, A. C. Rees, R. R. Bowers, C. M. Jones, S. G. Vaena, M. A. Clark, S. Carter, E. Villamor, D. Evans, A. J. Emanuel, G. Fullbright, D. T. Long, L. Spruill, M. J. Romeo, K. L. Helke, J. R. Delaney
This paper shows that combining MYC and p53-R270H mutations in a mouse model generates high-grade serous ovarian and uterine serous carcinomas with human-like genetic and transcriptomic features.
bioRxiv · Jan 24, 2024Cancer Biology