Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy
S. A. Mills, A. Jobling, M. A. Dixon, B. V. Bui, K. A. Vessey, J. A. Phipps, U. Greferath, G. Venables, V. H. Y. Wong, C. H. Y. Wong, Z. He, F. Hui, J. C. Young, J. Tonc, E. Ivanova, , E. L. Fletcher
This study shows microglia regulate retinal capillary constriction via fractalkine-Cx3cr1 signaling and RAS pathway, with dysfunction occurring early in diabetic retinopathy.
bioRxiv · Jun 15, 2020Cell Biology