Author

E. L. Fletcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

U. Greferath· 2 shared A. D. Dick· 1 shared A. J. Clare· 1 shared A. Jobling· 1 shared A. Pebay· 1 shared A. Senabouth· 1 shared A. W. Hewitt· 1 shared B. T. Richards· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

U. Greferath

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration

J. Liu, D. A. Copland, A. J. Clare, M. Gorski, B. T. Richards, L. Scott, S. Theodoropoulou, U. Greferath, K. Cox, O. H. Bell, K. Ou, J. L. B. Powell, J. Wu, L. Martinez Robles, Y. Li, , A. D. Dick

This study shows that replenishing IRAK-M in retinal pigment epithelium reduces outer retinal degeneration in age-related macular degeneration.

bioRxiv · Sep 27, 2023 · PreprintImmunology

Evolving Transcriptomic Signature of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cells With Age

G. E. Lidgerwood, A. Senabouth, C. J. A. Smith-Anttila, V. Gnanasambandapillai, D. C. Kaczorowski, D. Amann-Zalcenstein, E. L. Fletcher, S. H. Naik, A. W. Hewitt, J. Powell, A. Pebay

This study characterizes the transcriptomic changes in hPSC-derived RPE cells over time in culture, showing a maturing transcriptional profile that resembles native RPE.

bioRxiv · Jul 26, 2020Cell Biology

Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy

S. A. Mills, A. Jobling, M. A. Dixon, B. V. Bui, K. A. Vessey, J. A. Phipps, U. Greferath, G. Venables, V. H. Y. Wong, C. H. Y. Wong, Z. He, F. Hui, J. C. Young, J. Tonc, E. Ivanova, , E. L. Fletcher

This study shows microglia regulate retinal capillary constriction via fractalkine-Cx3cr1 signaling and RAS pathway, with dysfunction occurring early in diabetic retinopathy.

bioRxiv · Jun 15, 2020Cell Biology