Evolutionary repair reveals an unexpected role of the tRNA modification m1G37 in aminoacylation
B. E. Clifton, M. A. Fariz, G.-I. Uechi, P. Laurino
This study uses experimental evolution to show that loss of the tRNA modification m1G37 in E. coli is tolerated via compensatory mutations in the proline-tRNA ligase gene proS, revealing ProRS as a gatekeeper of translational accuracy.
Nucleic Acids Research · Nov 11, 2021Peer-reviewedBiochemistry